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Neuroanatomy in Rett Syndrome:Cerebral Cortex and Posterior Fossa Neurol 48:399-407, Subramaniam,B.,et al, 1997 See this aricle in Pubmed Article Abstract Patients with RS showed global reduction in gray and white matter volumes. The prefrontal,posterior-frontal and anterior-temporal regions showed the largest bilateral decrease in gray matter volume,whereas white matter volume was uniformly reduced throughout the brain.We found confirmation for the preferential reduction in caudate nucleus volume.However,we observed no preferential reduction in mid brain volume despite a preferential reduction in the mid sagittal area of this region.We also present an individual case comparison between monozygotic twins discordant for RS.

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